Murrells Inlet Real Estate | Murrells Inlet Commercial Properties for Sale

Opportunity to lease 1800 square feet of office warehouse flex space in Key Largo Commercial Park, situated along the Highway 17 corridor in Murrells Inlet, SC. The space offers approximately 220 square feet of conditioned office space, warehouse space with 2 drive in bays equipped with 11' overhead doors, and 25 foot vaulted ceiling heights. The Key Largo Commercial Park is an ideal location for residential and commercial service providers. Just off the corner of Eden Avenue and Highway 17 Bypass South, users have direct access to major traffic arteries and secondary streets. Neighboring tenants include Moro Roofing and Sheet Metal, Myrtle Beach Building Supply, and All Star Pool Company.

3625 Highway 17 Bypass Unit Unit A, Murrells Inlet

Listing courtesy of Listing Agent: Adam Hall () from Listing Office: Tradd Commercial.

$3,125

2622152 MLS

Brand-new construction medical/retail space now leasing alongside Seaside Dermatology at 5100 Hwy 17 Bypass. This 12,000 SF building offers 2,500 SF available and is configurable as two separate 1,250 SF suites or one combined 2,500 SF space. This prime location offers premium visibility and exposure directly on Hwy 17 Bypass, one of the area's busiest thoroughfares, which carries an AADT of approximately 36,700 vehicles per day. Positioned for strong daily traffic counts and easy accessibility, this is a rare opportunity to co-locate with an established dermatology practice in a fully new, move-in-ready shell. Potential flexible suite configurations, ample parking, and modern architectural finishes throughout. Projected completion March 2027. Ideal uses: dental, optometry, physical therapy, chiropractic, pediatrics, urgent care, veterinary, counseling/mental health, or professional office (law, financial, insurance, real estate). Ideal retail use: Boutique fitness/pilates studio, salon or barbershop, optical/eyewear shop, medical supply retailer, or specialty gift/apparel boutique — high-visibility space suited to service or specialty retail. Excludes: restaurants/food service, dermatology, and dermatology-adjacent services (med spa, aesthetics, laser hair removal, cosmetic/plastic surgery).

5100 Highway 17 Bypass, Murrells Inlet

Listing courtesy of Listing Agent: Taylor Keenan Team (Cell: 843-630-1166) from Listing Office: The Litchfield Company Real Estate.

$1,200,000

2621395 MLS

Income Producing Mobile Home Park in Murrells Inlet close to Beach and Intracoastal Waterway. It currently has nine homes that are occupied, as well as a tenth pad that is fully ready with electric, water and sewer. The Marina to the River and Intracoastal Waterway is 1 Mile South of the Property on Wachesaw Road. Huntington State Park is Only 2 Miles South. This 1.7 Acre parcel has approximately 43 Feet of Road Frontage

853 Wachesaw Rd., Murrells Inlet

Listing courtesy of Listing Agent: Bradley Lloyd () from Listing Office: Golden Peak Management Realty.

$1,450

2621150 MLS

OFFERED FOR LEASE: Approximately 1,250 SF 2nd Floor Office Space Situated on Approximately .59 Acres. Located between Highway 17 Bypass and Highway 17 Business. Less than 0.5 Miles from Inlet Square Mall. Close Proximity to the Murrells Inlet Marsh Walk, Garden City Pier, Tupelo Bay Golf Center, and Ocean Lakes Family Campground.

870 Inlet Square Dr., Murrells Inlet

Listing courtesy of Listing Agent: Gina Nelson () from Listing Office: Keystone Realty MB, LLC.

$15

2620929 MLS

Units 17 in the St. James Plaza is available for immediate occupancy. This 1200 square foot space unit is located in a local favorite food hub, featuring brands such as Drifrtwoods Steak and Seafood, Aroma's, and Habaneros. The plaza also benefits from an average daily traffic count of 25,000 (SCDOT) and a 3-mile population of nearly 40,000 (ESRI). Pylon signage, ample parking, and the adjacent Salem Road intersection make this location visible and accessible to a robust consumer base.

10799 Highway 707 Unit Unit 17, Murrells Inlet

Listing courtesy of Listing Agent: Adam Hall () from Listing Office: Tradd Commercial.

$5,600,000

2618801 MLS

Rare Grand Strand/Myrtle Beach opportunity: three-building commercial campus on ±6.76 acres (two parcels) with direct Highway 17 Bypass frontage in Murrells Inlet (±36,700 VPD). Two fully renovated office buildings (originally medical) feature generous private offices, efficient floor plans, and glassed conference rooms, move-in ready for clinic, dental, specialty practice, law, finance, engineering, or corporate HQ use. The third building is a ±10,000 SF fully conditioned office/warehouse with private offices, conference room, lounge, multiple restrooms, true warehouse space, and a whole-building backup generator. Site is served by public water/sewer, with three-phase power available from nearby utilities. Approx. 70 on-site parking spaces. Entitlements in place for two additional ±20,000 SF buildings with a cleared site, water retention, utilities, and engineering completed - true shovel-ready expansion. Seller will consider a partial sale-leaseback for immediate income or deliver the campus vacant for an owner-user. High-visibility location minutes to the Murrells Inlet MarshWalk, Inlet Square re-development, Brookgreen Gardens, Huntington Beach State Park, and the wider Grand Strand market. Ideal for owner-users, investors, and developers seeking office, medical, and flex capabilities with immediate upside. Murrells Inlet sits along the Grand Strand about 10-15 miles south of Myrtle Beach, straddling the Horry/Georgetown County line with direct access via Highway 17 Bypass. Known as the "seafood capital of South Carolina," it blends waterfront charm and tourism with a strong year-round base of retirees, families, and professionals, supporting medical, professional office, and flex/industrial uses. The area is minutes from the MarshWalk, Brookgreen Gardens, Huntington Beach State Park, and extensive retail and services along both the Bypass and Business 17, with Myrtle Beach International Airport roughly 20-25 minutes away. Demand is driven by steady population growth and seasonal visitors, reinforced by nearby hospital and medical clusters. Overall, it's a pro-growth coastal market attractive to owner users and investors seeking visible, accessible locations with ample amenities and infrastructure.

9250 Highway 17 Bypass, Murrells Inlet

Listing courtesy of Listing Agent: Gary Roberts () from Listing Office: CB Sea Coast Commercial.

$17,100

2617884 MLS

For Lease: turn-key freestanding medical office on 1.3 acres. Located at the corner of US-17 Bus and Eden Ave in Murrells Inlet near Ortho SC and Tidelands Health Waccamaw Community Hospital. Excellent ingress/egress with full access from US 17. Space consists of large lobby/waiting room, reception office, 4 exam rooms, 3 procedure rooms, doctor's office, nurses station, x-ray room, 4 restrooms, break room and multiple storage rooms. Pylon sign with digital board. Located within the Murrells Inlet submarket in Georgetown County near medical, retail, and high density residential. The Myrtle Beach MSA has been one of fastest growing MSA's in the US for the past 4 years. Permanent population within a 5 mile radius is 63,220. Average Daily Traffic on Hwy 17 is 41,900. Inlet Square Mall (Hobby Lobby, Belk, Floor & Decor, Planet Fitness, 2 new hotels, etc.) is located just north of subject property. Also, a new 4 story luxury apartment complex was recently completed on the opposite side of Hwy 17.

3583 Highway 17 Business Unit Former Southern Urgent Ca, Murrells Inlet

Listing courtesy of Listing Agent: Drew Parks () from Listing Office: CB Sea Coast Commercial.

$1,249,999

2616199 MLS

Prime commercial property for sale in Murrells Inlet, SC, located directly on Highway 17 Business with excellent visibility and exposure to both local and visitor traffic. Positioned less than one-half mile from the Murrells Inlet MarshWalk and surrounded by established restaurants, retail businesses, and tourist attractions, this property offers a unique owner-user or investment opportunity. The property has undergone substantial renovations since its previous sale and includes approximately 2,500 square feet of restaurant space featuring a spacious dining area, full-service beer and wine bar, and commercial kitchen setup. The sale includes the building, business, and most equipment, creating a turnkey opportunity for restaurant operators or entrepreneurs seeking a high-traffic coastal location. Additional income-producing opportunities include an approximately 900-square-foot commercial unit suitable for retail, office, salon, or professional service use, as well as an approximately 1,138-square-foot upstairs apartment or professional office space. The multiple-use configuration provides flexibility for owner occupancy, business operations, or rental income. Rare opportunity to acquire a renovated mixed-use commercial property with multiple revenue streams in one of the Grand Strand's most recognizable business districts. Buyer responsible for verification of all measurements, square footage, permitted uses, and information deemed important.

4378 Highway 17 Business, Murrells Inlet

Listing courtesy of Listing Agent: Houser & Co. Team () from Listing Office: CENTURY 21 Broadhurst.

$525

2615968 MLS

Looking establish a business presence in Murrells Inlet? This well-appointed executive office suite offers a professional setting with access to a shared conference room and break area. Lease includes water, sewer and electric for added convenience. Ideal for a small business or satellite office, this office is prominently located directly on Highway 17 By Pass, Murrells Inlet, providing easy access.

3955 Highway 17 Bypass Unit Unit C, Murrells Inlet

Listing courtesy of Listing Agent: Deby Emanuel () from Listing Office: Exit Coastal Real Estate Pros.

$2,795,000

2615699 MLS

4375 Hwy 17 S, Murrells Inlet

Listing courtesy of Listing Agent: Tony Cape (Cell: 843-999-2535) from Listing Office: NorthGroup Real Estate LLC.

$8,000

2615537 MLS

Class A Medical Office Space for Lease – Suite 103 4310 Highway 17 Bypass | Murrells Inlet, SC Suite 103 offers 3,557 square feet of premier Class A medical office space in one of Murrells Inlet's most advanced healthcare facilities. The Landlord is offering a generous Tenant Improvement Allowance, providing medical users the opportunity to customize the space to their exact operational and clinical requirements. Recently renovated throughout, the property is designed specifically to accommodate modern healthcare providers and offers a professional environment for physicians, specialists, outpatient services, and related medical uses. Tenants benefit from a comprehensive rental package with utilities, trash service, and janitorial service included in the rent, creating a highly efficient and predictable occupancy cost structure. The building features an impressive shared lobby designed to create a first-class patient experience, complete with a complimentary coffee bar and beverage station for patients and visitors. Additional amenities include dedicated patient and service elevators, monument signage opportunities, and approximately 160 parking spaces to comfortably accommodate patients and staff. The property is further enhanced by a Sentry 30 Security System, automatic water shut-off system after business hours, and a state-of-the-art Cosatron Air Purification System—a technology shared by only a select few facilities in the region, including Myrtle Beach International Airport. Further enhancing the property's medical ecosystem, a new surgery center is currently under construction on the second floor. Upon completion, the facility will feature nine pre-operative beds, nine post-operative recovery beds, and three operating rooms, including one lead-lined operating suite, creating a synergistic environment for physicians, surgeons, specialists, and ancillary healthcare providers. Conveniently located along the highly traveled Highway 17 Bypass corridor, the property offers excellent visibility, accessibility, and proximity to the rapidly growing Murrells Inlet, Garden City, Pawleys Island, and southern Grand Strand markets. Highlights- Ideal for medical and healthcare users Tenant Improvement Allowance Utilities, trash, and janitorial included in rent Recently renovated Class A medical building Shared lobby with complimentary coffee and beverage station Patient and service elevators Cosatron Air Purification System Sentry 30 Security System Automatic water shut-off system Monument signage available Approximately 160 parking spaces New ambulatory surgery center under construction Prime Highway 17 Bypass location in Murrells Inlet

4310 Highway 17 Business Unit Unit 103, Murrells Inlet

Listing courtesy of Listing Agent: Abernethy & Jones Commercial Group () from Listing Office: NAI The Litchfield Company.

$2,480

2611799 MLS

Planters Market Unit B offers approximately 1,750 square feet of versatile office or retail space in the highly desirable Murrells Inlet area. The property is ideally positioned directly across from the Inlet Square Mall, which is currently undergoing a major redevelopment into a planned 250,000-square-foot mixed-use destination featuring retail, medical offices, hotels, and multifamily residences. The suite features a functional and flexible layout, including a spacious front showroom with a reception area, complemented by four private offices in the rear. Additional amenities include a kitchenette and two private restrooms, making it well-suited for a variety of business types. Tenants will benefit from strong co-tenancy within Planters Market, joining established businesses such as Southside Grill, Guys & Dolls Hair Studio, Joli Visage, La Taqueria, Revive Massage, and Vinny’s Cafe.

804 Inlet Square Dr. Unit Suite B, Planters Market, Murrells Inlet

Listing courtesy of Listing Agent: Brad Davis () from Listing Office: Tradd Commercial.

$80,535

2611729 MLS

5300+ square feet for lease in one of the busiest shopping centers in Murrells Inlet. Woodside Village offers prime visibility at a signalized intersection on Highway 17 Bypass in Murrells Inlet, SC. This well-positioned, multi-anchor center benefits from strong traffic and excellent frontage. A diverse mix of retail, dining, services, and home improvement businesses draws customers from a 15-mile trade area. Nearby medical offices and a major hospital further boost daily traffic, making this an ideal location to grow your business. Vanilla box delivery will be available for any number of retail and office uses.

4430 Highway 17 South, Murrells Inlet

Listing courtesy of Listing Agent: Kenan Walker () from Listing Office: Circa Real Estate.

$1,700,000

2609919 MLS

Motivated Seller!! Located in the core of Garden city, the property is a well positioned commercial property formerly occupied by Dunes Realty, offering a recognizable location with established commercial use in place. The property is configured for professional office operations, featuring a functional layout that includes reception area, multiple private offices, and supporting workspace. This setup allows for immediate occupancy by office users while also presenting a clear path for conversion to retail, medical, or service-oriented uses. Permitted uses include office, medical, retail, salon/spa, fitness, financial services, and potential hospitality-related concepts such as boutique lodging or restaurant/bar (subject to approvals). This zoning flexibility is a key driver of long-term value and repositioning potential. Positioned just off the main coastal corridors and within close proximity to the Murrells Inlet MarshWalk, the property benefits from consistent local traffic, strong surrounding residential density, and ongoing growth throughout the southern Grand Strand.

128 Atlantic Ave., Murrells Inlet

Listing courtesy of Listing Agent: Bradley Lloyd () from Listing Office: Golden Peak Real Estate Group.

$4,998,000

2609722 MLS

A rare and lucrative investment opportunity awaits at Wachesaw Place in the heart of Murrells Inlet, featuring a portfolio of seven buildings totaling 28 multi-unit townhomes. These units offer a significant footprint in a high-demand rental market, characterized by spacious layouts, private screened porches, and access to a quiet community pool. Perfectly positioned for long-term growth, this substantial offering is ideal for investors looking to secure a major stake in the scenic South Carolina Lowcountry. Owner/Listing Agent is SC Realtor.

4601 Lomax Ct., Murrells Inlet

Listing courtesy of Listing Agent: Jimmy Smith () from Listing Office: James W Smith Real Estate Co.

$1,800,000

2608508 MLS

Prime Commercial Development & Investment Opportunity | Hwy 707 Corridor | 3.65 Acres An exceptional high-visibility commercial asset along the rapidly expanding Highway 707 corridor in Murrells Inlet, SC. Delivering immediate revenue, flexible zoning, and substantial future upside, this 3.65-acre site offers an ideal opportunity for developers, commercial end-users, or portfolio investors looking to capitalize on a high-growth market. Prime Highway Visibility: Prominent frontage on Hwy 707 capturing high exposure with 25,308 AADT (Annual Average Daily Traffic). In-Place Passive Revenue: Existing, income-producing billboard provides immediate cash flow upon acquisition. Flexible Zoning & Permitted Uses: Totaling 3.65 acres (0.35 acres RE2 + 3.3 acres CFA), supporting mixed-use, professional office, retail, or full redevelopment—including pre-approved/permitted uses for carwashes and self-storage facilities. Turnkey Existing Structure: Fully renovated 2,326 SF classic brick building features an upgraded kitchen and baths, flexible office layout (currently 2 bed/2 bath with office space; easily converted to 3 office suites), ideal for immediate commercial occupancy, adaptive reuse, or a professional live/work concept. Site Infrastructure & Utility: Features a private, fenced yard, dedicated outdoor storage areas, and ample space for parking expansions or ground-up construction. Unique Site Aesthetics: Lush natural buffers, mature landscaping, and an adjacent pond create an attractive, distinguished environment for clients, customers, and corporate headquarters. Whether securing a flagship location for an end-user, executing a commercial redevelopment plan, or holding a strategic cash-flowing asset in a top-performing corridor, this site yields maximum positioning and long-term value creation.

11091 Highway 707, Murrells Inlet

Listing courtesy of Listing Agent: Damon Barnwell (Cell: 843-267-0487) from Listing Office: The Litchfield Company Real Estate.

$3,670

2607997 MLS

Excellent opportunity to lease professional office space in the heart of Murrells Inlet with convenient access to both Highway 17 Business and Highway 17 Bypass. This well-maintained property offers strong accessibility, ample on-site parking, and monument signage available for each unit, providing excellent visibility for tenants. The building offers 3,000 SF total available, which can be leased as a single space or divided into 1,000 SF and 2,000 SF suites to accommodate a variety of professional users. The 2,000 SF suite is well designed for professional office use and features a welcoming reception area, conference room, multiple large executive offices, and nicely appointed office finishes throughout. The suite also includes approximately 600 SF of unfinished second-floor storage space, offering an excellent opportunity for future expansion into additional office space if desired. Tenants will also benefit from nicely appointed offices, dedicated break room areas, and functional layouts that can accommodate a range of professional or service-oriented businesses. Ownership is willing to provide a Tenant Improvement (TI) Allowance to assist with customization and tenant upfit. This is an ideal location for professional office, medical, or service-based users seeking quality space with excellent access and visibility in one of the Grand Strand’s most desirable business corridors.

5187 Horry Dr. Unit Unit B, Murrells Inlet

Listing courtesy of Listing Agent: Abernethy & Jones Commercial Group () from Listing Office: NAI The Litchfield Company.

$10,500

2605475 MLS

Versatile 3,500 sq ft commercial building designed for opportunity. Configure as one large unit or divide into two income-producing spaces. Ideal for investors seeking dual rental potential or business owners looking to offset occupancy costs. Build-to-suit options available — tailor the space to fit your brand and operational flow. Strong flexibility makes this property suitable for retail, office, medical, or service industries. Secure your footprint in a growing area with adaptable space that works for today’s business demands.

11935 Plaza Dr., Murrells Inlet

Listing courtesy of Listing Agent: Damiene Rogers () from Listing Office: Blue Print Real Estate LLC.

$3,000

2603477 MLS

Carney Center is a new multi-building flex development in the heart of Murrells Inlet offering exceptional visibility, access, and functionality for a wide range of commercial users. Four new construction buildings are currently underway, providing tenants the opportunity to secure space early and customize interiors to meet specific operational needs. This prime Highway 17 Bypass location features excellent exposure, ample parking, prominent signage opportunities, and convenient access for both customers and business owners. The development showcases attractive Lowcountry-inspired architecture with brick, Hardie plank siding, and metal accents, creating a clean, professional aesthetic with strong curb appeal. Front Buildings (Buildings 1 & 2) Divisible into: ±1,625 SF, ±2,250 SF, ±4,875 SF, or full ±6,500 SF suites ±6,500 SF each Rear roll-up garage doors included in all units Designed to accommodate office, showroom, and flex users Strong highway visibility and signage opportunities Rear Buildings (Buildings 3 & 4) ±6,500 SF each Divisible into: ±1,625 SF, ±2,250 SF, ±4,875 SF, or full ±6,500 SF suites Front roll-up doors with man doors for convenient access Ideal for service, storage, light industrial, or support operations Property Highlights New construction with tenant build-to-suit flexibility Ample on-site parking Excellent ingress/egress and circulation Functional layouts for office, showroom, warehouse, and service uses Roll-up doors included in all units Opportunity to lease front and rear units together for operational efficiency Carney Center is well-suited for contractors, service providers, medical or professional users, showroom operators, light industrial tenants, and businesses seeking a flexible, high-visibility Murrells Inlet location. Call today for availability, spec sheets, and pricing details—and secure your space before leasing is complete.

4960 Highway 17, Murrells Inlet

Listing courtesy of Listing Agent: Abernethy & Jones Commercial Group () from Listing Office: NAI The Litchfield Company.

$5,295

2603096 MLS

For Lease: 1,803 SF inline unit at Tournament Crossing, anchored by Walmart Neighborhood Market and located at the signalized intersection of Highway 17 Bypass and Tournament Blvd in Murrells Inlet. Strong tenant mix including AT&T, Tropical Smoothie Cafe, Domino's,Coastal Dental Group, Great Clips, Edward Jones, etc. Highly visible and easily accessible with multiple points of ingress/egress. Strong demographics show an affluent population base with over 73,396 households within a 5-mile radius, plus an influx of visitors throughout the year. Average daily traffic count on Hwy 17 Bypass is 36,500. Located within the Murrells Inlet submarket in Horry County. The Myrtle Beach MSA has been one of fastest growing MSA's in the US for the past 3 years. Permanent population within a 5 mile radius is 73,396. Average Daily Traffic on Hwy 17 Byp is 36,500. A new 4 story luxury apartment complex was recently completed on the frontage road just south of the subject property. Inlet Square Mall on opposite side of Hwy 17 Byp is under redevelopment, with Hobby Lobby, Floor & Decor, Planet Fitness, Belk, and 2 new hotels.

11990 Highway 17 Bypass Unit Unit 7, Tournament Crossi, Murrells Inlet

Listing courtesy of Listing Agent: Drew Parks () from Listing Office: CB Sea Coast Commercial.

$525

2600053 MLS

Looking establish a business presence in Murrells Inlet? This well-appointed executive office suite offers a professional setting with access to a shared conference room and break area. Lease includes water, sewer and electric for added convenience. Ideal for a small business or satellite office, this office is prominently located directly on Highway 17 By Pass, Murrells Inlet, providing easy access.

3955 Highway 17 Bypass Unit Unit B, Murrells Inlet

Listing courtesy of Listing Agent: Deby Emanuel () from Listing Office: Exit Coastal Real Estate Pros.

$2,150,000

2527809 MLS

Strategically positioned along the bustling Hwy 17 Bypass, this high-end car wash offers prime visibility and exceptional access in one of the Grand Strand’s most rapidly growing markets. With over 40,200 vehicles passing daily per SCDOT data, this property stands as a rare investment opportunity in coastal South Carolina. Property Highlights: Total Area: 1.08 acres with 85’ road frontage & direct ingress/egress on Hwy 17 bypass. Building Size: 2,686 heated sq. ft. | 3,590 total sq. ft. Exterior: Durable Hardie-Plank siding with standing seam metal roof. Flood Zone: X. Facility Breakdown: Car Wash Tunnel: 1,600 sq. ft. equipped with tunnel system. New blowers (2021), chain & rollers (2021), and a proportionator added April 2024 — expected 20-year lifespan. Hand Wash Bay: 648 sq. ft. Covered Patio Waiting Area: 256 sq. ft. Office/Operations: 1,050 sq. ft. for restrooms, lobby, equipment. An additional 86 sq. ft. of private back office space. Lighting: Full interior & exterior system replaced in 2025. Annual Equipment Service: Performed each September.

4920 Highway 17 Bypass, Murrells Inlet

Listing courtesy of Listing Agent: Mo Paul's Team () from Listing Office: Salt Realty.

$650

2522209 MLS

For Lease: 12x16 office on the 2nd floor (no elevator) of professional office building in Murrells Inlet. Common restroom and kitchenette. Located east of Hwy 17 near the Wachesaw Rd intersection, in close proximity to Tidelands Health Waccamaw Hospital. Ground Floor is occupied by MD 4 Vitality, Hair Health and 2 attorneys. Located within the Murrells Inlet submarket in Georgetown County. The Myrtle Beach MSA has been one of fastest growing MSA's in the US for the past 3 years. Permanent population within a 5 mile radius is 40,357.

641 Little Tony Ave. Unit 2nd Floor, Suite 1, Murrells Inlet

Listing courtesy of Listing Agent: Drew Parks () from Listing Office: CB Sea Coast Commercial.

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